I presume you mean when flashing to a FlashBoy\Plus? If so, yes.
Try using different usb ports and use the included USB cable and it should work.
My PC has several USB ports, and only one of them works with the cart/software. I also tried using a different USB cable with it in the correct port, and it gave the same error. When using the included USB cable in the correct port, it flashed with no errors.
Yea, that’s what it was. It’s a shame all my usb ports are on the back of the computer. Seem’s like I can’t use an extender or hub. But, that’s oki it’s worth it.