I have integrated Marc Robledo’s Rom Patcher JS into the website. You’ll now find a button next to each patch download that allows you to directly apply the respective patch file to a game ROM file you supply. For example here, look for the yellow button for the “Save Support” patch on the left side.
There’s also a standalone version that allows you to select any patch from your hard drive or even create patches from modified ROM files. Try it at https://www.virtual-boy.com/patch/.